H70 - H70 Cohort 5 - Follow-up 3
Participants are 85 years old at this follow-up.The psychiatric examinations were performed by psychiatrists and include ratings of psychiatric symptoms and signs with Comprehensive Psychopathological Rating Scale, Mini-D, tests of mental functioning (e.g. memory), Mini Mental State Examination, other signs common in dementia, personality inventories (Five Factor Model, EPI) and questions about previous mental disorders, sexuality, sleep, and suicidal behavior.
Somatic examinations include assessment of medical conditions (e.g. hypertension, myocardial infarction, angina pectoris, stroke, cardiac failure, atrial fibrillation, diabetes mellitus, pulmonary diseases, fractures, thyroid diseases, head trauma, cancer), the Cumulative Illness Rating Scale for Geriatrics, anthropometric measurements, blood pressure, ECG, lung function, measures of atherosclerosis, body composition (dexa), grip strengths and walking capacity. Questions are asked about urinary function, falls, dizziness, alcohol and tobacco use, family history of psychiatric and somatic disorders, and use of health services. Blood samples are taken and include e.g. hemoglobin, HbA1c, cholesterol (HDL, LDL), and homocysteine. Blood, serum and plasma are frozen for future analyses.
Psychological examinations assess memory and intelligence using SRB-1, SRB-2, SRB-3, Thurstone Picture Memory, Ten Word Memory List, Clock Test, Prose Recall, and Digit Span. Functional ability data is collected on basic abilities in ADL, and iADL (Katz, Lawton).
Social factors data are collected on socioeconomic status, marital status, living conditions, social network, education, hobbies, cultural activities and life events.
Close informant interview comprises IQCODE, questions on changes in behavior and intellectual function, psychiatric symptoms, ADL/iADL, family history, medical history and onset and course of dementia. Genetic epidemiology DNA is extracted from whole blood using a standard procedure. The DNA samples are genotyped using the large scale (approx 500 000 genetic markers) Infinium Neuro Consortium Array (NeuroChip) from Illumina, including a GWAS-part together with a custom-made part focusing on neurodegenerative disorders. Additional single SNPs of specific interest have been/will be analyzed with allele-specific amplification methods for genotyping, such as KASPar.
Dementia, depression, psychotic disorders, sleep disorders, obsessive-compulsive disorder, anxiety disorders (social phobia, specific phobia, panic disorder, generalized anxiety disorder) and post-traumatic stress disorder are diagnosed according to DSM-III-R, DSM-IV or DSM-5. Somatic disorders are classified according to established criteria, using information from examinations, close informants, and hospital register data.