KP - KP15 - Phase III
All participants were interviewed by nurses, clinically examined by physicians, and assessed by psychologists.
The nurses measured blood pressure, height, and weight, collected blood samples, and assessed cognitive status with brief cognitive tasks as well as assessing physical functioning in terms of activities of daily living and instrumental activities of daily living.
The clinical examination was similar to a comprehensive somatic, neurological, and psychiatric examination usually performed in clinical practice, but was structured and defined according to various scoring criteria. The examination included family medical history with a structured family interview of all first-degree relatives, personal clinical history, retrospective cognitive assessment and clinical examination. At the end, the examiner made diagnoses of current diseases according to standardized criteria. All diagnoses were reviewed by two senior clinicians.
A family interview with a next-of-kin or a close person was carried out. The interview concerned past and current health status of the subject, as well as selective risk factors of the most common chronic neurodegenerative diseases. Information was gathered on specific topics, such as detailed occupational-life history, caregiver burden, and use of home help and home services.
The psychological examination included a comprehensive assessment of memory and other cognitive functions, including tests of episodic memory, short-term memory, verbal ability, visuospatial skill, spatial orientation, perceptual speed and executive functions.