Individual Study / Betula

Betula Study

Betula Study

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Networks -
Datasets -
Variables -
Start Year
1988
End Year
2014
Supplementary Information

Nilsson, L.-Gör., Bäckman, L., Erngrund, K., et al. The Betula Prospective Cohort Study: Memory, Health, and Aging. Aging, Neuropsychology, and Cognition,1997; 4(1), 1–32.

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Investigators Contacts
  • Prof. Lars Nyberg
    Umeå universitet
  • Dr. Anna Sundström
    Umeå universitet
  • Dr. Michael Rönnlund
    Umeå universitet
  • Pr. Rolf Adolfsson
    Umeå universitet
  • Mikael Stiernstedt
    Umeå universitet

Design

Study design
Cohort
Follow Up
The participants were assessed at 6 different time points every 5 years: in 1988-1990, 1993-1995, 1998-2000, 2003-2005, 2008-2010 and 2013-2014.
Supplementary Information

Marker Paper

Nilsson L-G, Adolfsson R, Bäckman L, de Frias C, Molander B, Nyberg L. Betula: A Prospective Cohort Study on Memory, Health and Aging. Aging, Neuropsychology and Cognition,2004; 11 (2-3), 134-148.

Recruitment

Sources of Recruitment
  • Individuals

Number of participants

Number of participants
4,425
Number of participants with biosamples
4,300
Supplementary Information

Access

Availability of data and biosamples

Possible Access to Data
Possible Access to Biosamples
Other
A sub-sample of participants underwent MRI brain scanning at test wave 5 (2009-2010) and 6 (2013-2014).

Supplementary Information

1. Zimbardo Time Perspective Inventory Based on: (ZTPI) Zimbardo o. Boyds skala (Zimbardo, P., and Boyd, J. N. (1999). Used in Betula: Carelli, M. G., Wiberg, B., & Wiberg, M. (2011). Development and Construct Validation of the Swedish Zimbardo Time Perspective Inventory. European Journal of Psychological Assessment, 27(4), 220–227. https://doi.org/10.1027/1015-5759/a000076

2. Patient Health Questionnaire-9 Based on: Kroenke, K., Spitzer, RL. & Willimas, JB. (2001). The PHQ-9: validity of a brief depression severity measure. Journal of General Internal Medicine, 16(9), 606-613. https://doi.org/10.1046/j.1525-1497.2001.016009606.x Used in Betula: translated version.

3. Perceived Stress Questionnaire Based on: Levenstein S, Prantera C, Varvo V, Scribano ML, Berto E, Luzi C, Andreoli A. Development of the Perceived Stress Questionnaire: a new tool for psychosomatic research. J Psychosom Res 1993;37:19–32. https://doi.org/10.1016/0022-3999(93)90120-5.

Bergdahl, J., and Bergdahl, M. (2002). Perceived stress in adults: prevalence and association of depression, anxiety and medication in a Swedish population. Stress Health 18, 235–241. doi: 10.1002/smi.946 Used in Betula: translated version.

4. Seasonal Pattern Assessment Questionnaire Based on: Rosenthal, NE., Sack, DA., Gillin, JC., Lewy AJ., Goodwin, FK., Davenport, Y., Mueller, PS., Newsome, DA. & Wehr, TA. (1984). Seasonal affective disorder. A description of the syndrome and preliminary findings with light therapy. Arch Gen Psychiatry, 41(1), 72-80. https://doi.org/10.1001/archpsyc.1984.01790120076010 Used in Betula: translated version

Timeline

Populations

Selection Criteria
Minimum age
35
Maximum age
80
Newborns
Twins
Countries
  • Sweden
Territory
Municipality of Umeå, Västerbotten
Ethnic Origin
Health Status
Other criteria
When participants entered the study, they were excluded if they had a severe visual or auditory disability, intellectual disability, dementia or a native language other than Swedish.

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample

Number of participants

Number of participants
1,000
Number of participants with biosamples
Supplementary Information
T1: 1000 participants
T2: 875 participants
T3: 729 participants
T4: 591 participants
T5: 403 participants
T6: 249 participants
Data Collection Events
# Name Description Start End
0 Betula - Cohort 1 - T1 1988-11 1991-04
1 Betula - Cohort 1 - T2 1993-09 1995-09
2 Betula - Cohort 1 - T3 1998-09 2001-03
3 Betula - Cohort 1 - T4 2003-09 2005-11
4 Betula - Cohort 1 - T5 2008-10 2010-03
5 Betula - Cohort 1 - T6 2013-09 2014-07
Selection Criteria
Minimum age
35
Maximum age
80
Newborns
Twins
Countries
  • Sweden
Territory
Municipality of Umeå, Västerbotten
Ethnic Origin
Health Status
Other criteria
When participants entered the study, they were excluded if they had a severe visual or auditory disability, intellectual disability, dementia or a native language other than Swedish.

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample

Number of participants

Number of participants
994
Number of participants with biosamples
Supplementary Information
T1: 994 participants
T2: 681 participants
Data Collection Events
# Name Description Start End
0 Betula - Cohort 2 - T1 1993-09 1995-09
1 Betula - Cohort 2 - T2 1998-09 2001-03
Selection Criteria
Minimum age
40
Maximum age
84
Newborns
Twins
Countries
  • Sweden
Territory
Municipality of Umeå, Västerbotten
Ethnic Origin
Health Status
Other criteria
When participants entered the study, they were excluded if they had a severe visual or auditory disability, intellectual disability, dementia or a native language other than Swedish.

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample

Number of participants

Number of participants
963
Number of participants with biosamples
Supplementary Information
T1: 963 participants
T2: 826 participants
T3: 689 participants
T4: 440 participants
T5: 259 participants
Data Collection Events
# Name Description Start End
0 Betula - Cohort 3 - T1 1993-09 1995-09
1 Betula - Cohort 3 - T2 1998-09 2001-03
2 Betula - Cohort 3 - T3 2003-09 2005-11
3 Betula - Cohort 3 - T4 2008-10 2010-03
4 Betula - Cohort 3 - T5 2013-09 2014-07
Selection Criteria
Minimum age
35
Maximum age
90
Newborns
Twins
Countries
  • Sweden
Territory
Municipality of Umeå, Västerbotten
Ethnic Origin
Health Status
Other criteria
When participants entered the study, they were excluded if they had a severe visual or auditory disability, intellectual disability, dementia or a native language other than Swedish.

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample

Number of participants

Number of participants
553
Number of participants with biosamples
Supplementary Information
T1: 553 participants
Data Collection Event
Start Date
1998-09
End Date
2001-03
Data sources
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
Data sources - Biosamples
  • Blood
  • Urine
Selection Criteria
Minimum age
35
Maximum age
95
Newborns
Twins
Countries
  • Sweden
Territory
Municipality of Umeå, Västerbotten
Ethnic Origin
Health Status
Other criteria
When participants entered the study, they were excluded if they had a severe visual or auditory disability, intellectual disability, dementia or a native language other than Swedish.

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample

Number of participants

Number of participants
558
Number of participants with biosamples
Supplementary Information
T1: 558 participants
Data Collection Event
Start Date
2003-09
End Date
2005-11
Data sources
  • Questionnaires
  • Cognitive measures
  • Physical measures
  • Biosamples
Data sources - Biosamples
  • Blood
  • Urine
  • Saliva
Selection Criteria
Minimum age
25
Maximum age
80
Newborns
Twins
Countries
  • Sweden
Territory
Municipality of Umeå, Västerbotten
Ethnic Origin
Health Status
Other criteria
When participants entered the study, they were excluded if they had a severe visual or auditory disability, intellectual disability, dementia or a native language other than Swedish.

Recruitment

Sources of recruitment
  • General population
General Population
  • Selected sample

Number of participants

Number of participants
357
Number of participants with biosamples
Supplementary Information
T1: 357 participants
T2: 66 participants
Data Collection Events
# Name Description Start End
0 Betula - Cohort 6 - T1 2008-10 2010-03
1 Betula - Cohort 6 - T2 2013-09 2014-07